Progressive neurologic dysfunction in a psoriasis patient treated with dimethyl fumarate

Case report of a patient with progressive multifocal leukoencephalopathy under treatment with dimethyl fumarate

BACKGROUND Progressive multifocal leukoencephalopathy is a severe demyelinating disease caused by the polyoma JC virus in patients with reduced immunocompetence. A few cases of progressive multifocal leukoencephalopathy have been reported in patients treated with fumaric acid esters. CASE PRESENTATION A 53-year-old Caucasian woman reported to our clinic with a first focal epileptic seizure an...

Nonfatal PML in a patient with multiple sclerosis treated with dimethyl fumarate

Dimethyl fumarate (DMF) is an oral medication for multiple sclerosis (MS) that is prescribed in part for its favorable safety profile. There have been 5 reported cases of progressive multifocal leukoencephalopathy (PML) with the use of fumaric acid esters in patients with psoriasis. Some have been on concomitant or prior immunosuppression and most had absolute lymphocyte counts (ALC) below 500....

A Patient with Interstitial 5q21 Deletion, Familial Adenomatous Polyposis, Dysmorphic Features, and Profound Neurologic Dysfunction

     Familial adenomatous polyposis (FAP) is a hereditary autosomal dominant cancer syndrome, results from germ line mutation or deletion of the Adenomatous Polyposis Coli (APC) gene on chromosome 5q21. Patients with FAP suffer from multiple polyps mainly at the colorectal region as well as other parts of the gastrointestinal tract, which has propensity to transform into carcinoma. FAP has also...

Dimethyl fumarate and progressive multifocal leucoencephalopathy (PML) Introduction

Introduction Dimethyl fumarate Psorinovo® is not registered through the Medicines Evaluation Board (MEB). It is a compounded drug made by GMP compounding pharmacy Mierlo Hout in the Netherlands, and used for the indication psoriasis [1]. Psorinovo® has been compounded by pharmacy Mierlo Hout for 28 years. According to Dutch law Mierlo Hout pharmacy is regarded as a supplying-pharmacy. Dimethyl ...

Progressive multifocal leukoencephalopathy during fumarate monotherapy of psoriasis